Laninamivir |
| Catalog No.GC65069 |
Le laninamivir (R 125489) est un puissant inhibiteur de la neuraminidase (NA) de la grippe avec des CI50 de 0,90 nM, 1,83 nM et 3,12 nM pour les virus H12N5 aviaire (N5), pH1N1 N1 NA (p09N1) et A/RI/5+/ 1957 H2N2 N2 (p57N2), respectivement.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 203120-17-6
Sample solution is provided at 25 µL, 10mM.
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Laninamivir (R 125489) is a potent influenza neuraminidase (NA) inhibitor with IC50s of 0.90 nM, 1.83 nM and 3.12 nM for avian H12N5 NA (N5), pH1N1 N1 NA (p09N1) and A/RI/5+/1957 H2N2 N2 (p57N2), respectively[1].
Laninamivir (R 125489) inhibits efficiently common oseltamivir-resistant viruses, including those with the ubiquitous His274Tyr substitution[1].Laninamivir (R 125489) is potent against p57N2, p09N1 and N5 with a similar binding mode to Zanamivir[1].
[1]. Vavricka CJ, et al. Structural and functional analysis of laninamivir and its octanoate prodrug reveals group specific mechanisms for influenza NA inhibition. PLoS Pathog. 2011 Oct;7(10):e1002249.
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