Lapaquistat acetate (Synonyms: TAK-475) |
| Catalog No.GC38807 |
L'acétate de lapaquistat (TAK-475) est un inhibiteur de la squalène synthase, bloquant la conversion du farnésyl diphosphate (FPP) en squalène dans la voie de biosynthèse du cholestérol .
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Cas No.: 189060-13-7
Sample solution is provided at 25 µL, 10mM.
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Lapaquistat acetate (TAK-475) is a squalene synthase inhibitor, blocking the conversion of farnesyl diphosphate (FPP) to squalene[1]. Lapaquistat acetate (TAK-475) is originally intended use to Mevalonate Kinase Deficiency (MKD), it is effective at lowering low-density lipoprotein cholesterol, but it might cause liver damage[2].
[1]. Stein EA, et al. Lapaquistat acetate: development of a squalene synthase inhibitor for the treatment of hypercholesterolemia. Circulation. 2011 May 10;123(18):1974-85. [2]. Marcuzzi A, et al. Repositioning of Tak-475 In Mevalonate Kinase Disease: Translating Theory Into Practice. Curr Med Chem. 2018;25(24):2783-2796.
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