LCC-12 (formate) |
| Catalog No.GC91059 |
Un chélateur de cuivre (II) et un dérivé de la metformine.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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LCC-12 is a copper (II) chelator and derivative of the biguanide metformin .1 It binds copper (II) as a monomer and reduces its drogen peroxide-dependent oxidation of NADH to NAD+ when used at a concentration of 20 µM. LCC-12 (10 µM) decreases the levels of the cytokines IL-1β, IL-2, IL-6, IL-8, and TNF-α, as well as levels of JAK2, STAT2, and IL-1 receptor-associated kinase 4 (IRAK4), in primary human cytokine-activated monocyte-derived macrophages (MDMs). It reduces the numbers of CD80+ and CD86+ cytokine-activated MDMs when used at a concentration of 10 µM. LCC-12 (0.3 mg/kg per day) increases survival in mouse models of sepsis induced by LPS or cecal ligation and puncture.
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