LP 922056 |
Catalog No.GC50548 |
Le LP 922056 est un inhibiteur de la pectinacétylestérase de Notum hautement actif par voie orale avec des CE50 de 21 nM, 55 nM dans les tests cellulaires humains et murins, respectivement.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1365060-22-5
Sample solution is provided at 25 µL, 10mM.
Notum pectinacetylesterase inhibitor. Activates wnt signalling in vitro (EC50 values are 21 nM in human and 55 nM in mouse cell-based assay). Increases cortical bone thickness in mouse model of bone growth.
Tarver et al (2016) Stimulation of cortical bone formation with thienopyrimidine based inhibitors of Notum Pectinacetylesterase. Bioorg.Med.Chem.Lett 26 1525 PMID:26897593 |Brommage et al (2019) NOTUM inhibition increases endocortical bone formation and bone strength. Bone Res. 7 PMID:30622831
Average Rating: 5
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