Mal-amido-PEG6-NHS ester |
| Catalog No.GC65016 |
L'EGFR-IN-16 (composé 3) est un puissant inhibiteur de l'EGFR avec une pIC50 de 4,85 et 4,74 pour l'EGFR et HER-2, respectivement.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1137109-21-7
Sample solution is provided at 25 µL, 10mM.
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Mal-amido-PEG6-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.
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