Minerval (Synonyms: 2-hydroxy-9-cis-Octadecenoic Acid, α-hydroxy-9-cis-Octadecenoic Acid, 2-OHOA, SML 0256) |
| Catalog No.GC38817 |
Minerval (acide 2-hydroxyoléique) est un dérivé synthétique de l'acide oléique (OA) qui se lie À la membrane plasmique et modifie l'organisation des lipides. Minerval a un effet anti-tumoral.
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Cas No.: 56472-29-8
Sample solution is provided at 25 µL, 10mM.
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Minerval (2-Hydroxyoleic acid) is a synthetic oleic acid (OA) derivative that binds to the plasma membrane and alters lipid organization. Minerval has anti-tumor effect[1].
Minerval (25-75 μM; 72 hours) impairs Jurkat cell growth in a time- and concentration-dependent manner, with an IC50 of ~40 μM[1].Minerval (25-50 μM; 72 hours) also induces a marked and concentration-dependent increase in the proteolytic cleavage of PARP, a molecular marker of apoptosis[1]. Cell Viability Assay[1] Cell Line: Jurkat cells
Minerval markedly and significantly inhibits tumour growth in nude mice infected with Jurkat cells[1]. Animal Model: 6-week-old nude male mice (Jurkat cells xenograft model)[1]
[1]. Llado V, et al. Minerval induces apoptosis in Jurkat and other cancer cells. J Cell Mol Med. 2010 Mar;14(3):659-70.
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