MK-8998 (Synonyms: MK-8998) |
Catalog No.GC19252 |
MK-8998 (MK-8998; composé 33) est un inhibiteur puissant et sélectif du canal calcique de type T.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 953778-58-0
Sample solution is provided at 25 µL, 10mM.
MK-8998 is a potent and selective antagonist of the T-type calcium channel.
MK-8998 is a potent and selective antagonist of the T-type calcium channel that is being investigated as a potential new therapy for the treatment of schizophrenia. Because MK-8998 does not block D2, 5HT2a, muscarinic, or histaminic receptors, it has the potential for a substantially improved side effect profile compared with currently available atypical antipsychotics[1].
MK-8998 is not effective in treating acutely psychotic inpatients with schizophrenia. There are no significant differences between either MK-8998 or olanzapine versus placebo at any time point. MK-8998 and olanzapine are generally well tolerated but are associated with a higher percentage of adverse events compared with placebo[1].
References:
[1]. Egan MF, et al. Randomized controlled study of the T-type calcium channel antagonist MK-8998 for the treatment of acute psychosis in patients with schizophrenia. Hum Psychopharmacol. 2013 Mar;28(2):124-33.
Average Rating: 5
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