ML-137 (Synonyms: VU0366369) |
| Catalog No.GC91500 |
ML-137 is a positive allosteric modulator (PAM) of M1 muscarinic acetylcholine receptors (mAChRs).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1222834-53-8
Sample solution is provided at 25 µL, 10mM.
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ML-137 is a positive allosteric modulator (PAM) of M1 muscarinic acetylcholine receptors (mAChRs).[1] It is selective for M1 over M2-M5 mAChRs at 30 µM. ML-137 potentiates ACh-induced activation of the M1 muscarinic receptor (EC50 = 0.83 µM).
References:
[1].Bridges, T.M., Phillip Kennedy, J., Noetzel, M.J., et al.Chemical lead optimization of a pan Gq mAChR M1, M3, M5 positive allosteric modulator (PAM) lead. Part II: Development of a potent and highly selective M1 PAMBioorg. Med. Chem. Lett.20(6)1972-1975(2010).
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