MLS1082 |
| Catalog No.GC70554 |
MLS1082 est un modulateur allostérique positif des récepteurs de la dopamine de type D1 à base de Pyrimidone avec une CE50 de 123 nm pour la signalisation de la protéine G stimulée par la da.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 883958-36-9
Sample solution is provided at 25 µL, 10mM.
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MLS1082 potentiate β-Arrestin- and G protein-Mediated D1R signaling[1].
References:
[1]. Kathryn D Luderman, et al. Development of pyrimidone D1 dopamine receptor positive allosteric modulators. Bioorg Med Chem Lett. 2021 Jan 1;31:127696.
[2]. Kathryn D Luderman, et al. Identification of Positive Allosteric Modulators of the D 1 Dopamine Receptor That Act at Diverse Binding Sites. Mol Pharmacol. 2018 Oct;94(4):1197-1209.
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