MRTX-EX185 |
Catalog No.GC64452 |
MRTX-EX185 est un puissant inhibiteur de KRAS et KRAS(G12D) chargés de GDP, avec une IC50 de 90 nM pour KRAS(G12D). Le MRTX-EX185 lie également le HRAS chargé par GDP.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
MRTX-EX185 is a potent inhibitor of GDP-loaded KRAS and KRAS(G12D), with an IC50 of 90 nM for KRAS(G12D). MRTX-EX185 also binds GDP-loaded HRAS[1].
[1]. Vasta JD, et, al. KRAS is vulnerable to reversible switch-II pocket engagement in cells. Nat Chem Biol. 2022 Mar 21.
Average Rating: 5
(Based on Reviews and 30 reference(s) in Google Scholar.)GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
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