MSN-125 |
| Catalog No.GC61096 |
MSN-125 est un puissant inhibiteur d'oligomérisation de Bax et Bak. MSN-125 empêche la perméabilisation de la membrane externe mitochondriale (MOMP) avec une IC50 de 4 μM. MSN-125 inhibe puissamment l'apoptose médiée par Bax/Bak dans les cellules HCT-116, BMK et les neurones corticaux primaires, protège les neurones primaires contre l'excitotoxicité au glutamate.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1592908-16-1
Sample solution is provided at 25 µL, 10mM.
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MSN-125 is a potent Bax and Bak oligomerization inhibitor. MSN-125 prevents mitochondrial outer membrane permeabilization (MOMP) with an IC50 of 4 μM. MSN-125 potently inhibits Bax/Bak-mediated apoptosis in HCT-116, BMK Cells, and primary cortical neurons, protects primary neurons against glutamate excitotoxicity[1].
MSN-125 inhibits tBid/Bax-mediated MOMP in a concentration-dependent manner[1].
[1]. Niu X, et al. A Small-Molecule Inhibitor of Bax and Bak Oligomerization Prevents Genotoxic Cell Death and Promotes Neuroprotection. Cell Chem Biol. 2017 Apr 20;24(4):493-506.e5.
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