MZ1 |
| Catalog No.GC18729 |
MZ1 est un PROTAC connecté par des ligands pour von Hippel-Lindau et BRD4. MZ1 induit puissamment et rapidement une élimination réversible, durable et sélective de BRD4 sur BRD2 et BRD3. Kds de 382/120, 119/115 et 307/228 nM pour BRD4 BD1/2, BRD3 BD1/2 et BRD2 BD1/2, respectivement.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1797406-69-9
Sample solution is provided at 25 µL, 10mM.
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MZ1 is a hybrid compound that drives the selective proteasomal degradation of bromodomain-containing protein 4 (BRD4). It is characterized as a proteolysis-targeting chimera (PROTAC) and contains JQ-1, which binds bromo- and extra-terminal (BET) proteins, linked to a ligand for the E3 ubiquitin ligase VHL. MZ1 induces the selective degradation of BRD4 in HeLa cells when used at 0.1-0.5 uM. At concentrations of 2-10 uM, MZ1 causes the removal of BRD2, BRD3, and BRD4. BRD protein removal is evident within four hours of adding MZ1 and persists for at least 48 hours, unless MZ1 is removed.
Review for MZ1
Average Rating: 5 (Based on Reviews and 40 reference(s) in Google Scholar.)
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