Nampt activator-3 |
| Catalog No.GC71068 |
Nampt activator-3 Le dérivé de Nat est un activateur de nampt avec une CE50 de 2,6 µm et une KD de 132 nm.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2790481-63-7
Sample solution is provided at 25 µL, 10mM.
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NAMPT activator-3 (compound 72; 0.1, 0.3, 1, 3, 10 μM; 72 hours) exertes no side effect on the cell viability including osteosarcoma cells (U2OS), glioblastoma cells (T98G), neuroblastoma cells (SH-SY5Y) and liver carcinoma cells (HepG2)[1].
NAMPT activator-3 (compound 72) protects peripheral sensory neurons from Taxol -induced damage by enhancing NAD production[1].
Pharmacokinetic Parameters of NAMPT activator-3 in mice[1].
| IV (1 mg/kg) | IP (30 mg/kg) | PO (30 mg/kg) | |
| Tmax (h) | 0.25 | ||
| Cmax (ng/mL) | 1563 | 188 | |
| AUClast (h∗ng/mL) | 183 | 1333 | 388 |
| T1/2 (h) | 0.18 | 1.05 | 1.34 |
| CL (mL/min/kg) | 90.4 | ||
| Vss (mL/kg) | 1130 | ||
| F (%) | 24.2 | 7.05 |
References:
[1]. Leibo Wang, et al. Optimization of NAMPT activators to achieve in vivo neuroprotective efficacy. Eur J Med Chem. 2022 Jun 5;236:114260.
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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