NL-1 |
| Catalog No.GC39411 |
NL-1 est un inhibiteur de mitoNEET À effet antileucémique. NL-1 inhibe la croissance des cellules REH et REH/Ara-C avec des IC50 de 47,35 μM et 56,26 μM, respectivement. La mort médiée par NL-1 dans les cellules leucémiques nécessite l'activation de la voie autophagique.
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Cas No.: 188532-26-5
Sample solution is provided at 25 µL, 10mM.
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NL-1 is a mitoNEET inhibitor with antileukemic effect. NL-1 inhibits REH and REH/Ara-C cells growth with IC50s of 47.35 µM and 56.26 µM, respectively. NL-1-mediated death in leukemic cells requires the activation of the autophagic pathway[1].
[1]. Geldenhuys WJ, et al. The MitoNEET Ligand NL-1 Mediates Antileukemic Activity in Drug-Resistant B-Cell Acute Lymphoblastic Leukemia. J Pharmacol Exp Ther. 2019 Jul;370(1):25-34.
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