O-Desmethyl-cis-tramadol (hydrochloride) (Synonyms: O-Desmethyltramadol)

O-Desmethyl-cis-tramadol (hydrochloride) is an analytical reference material that is structurally categorized as an opioid. It is the main metabolite of cis-tramadol . O-Desmethyl-cis-tramadol has ~400-500-fold higher affinity for u-opioid receptors than the parent compound. However, O-desmethyl-cis-tramadol poorly suppresses the human serotonin transporter, unlike cis-tramadol. This product is intended for research and forensic applications. This product is a qualified Reference Material (RM) that has been manufactured and tested to meet ISO17025 and Guide 34 guidelines. These materials are tested using validated analytical methods on qualified instrumentation to ensure traceability of measurements. All traceable RMs may be distinguished by their CofAs and can be downloaded below using the batch number located on the product label. For a representative CofA please contact our technical support.

References:
[1]. Leppert, W. CYP2D6 in the metabolism of opioids for mild to moderate pain Pharmacology 87(5-6), 274-285 (2011).
[2]. Barann, M., Urban, B., Stamer, U., et al. Effects of tramadol and O-demethyl-tramadol on human 5-HT reuptake carriers and human 5-HT3A receptors: A possible mechanism for tramadol-induced early emesis European Journal of Pharmacology 531(1-3), 54-58 (2006)