ω-Hydroxy-DEET |
| Catalog No.GC61990 |
ω-Hydroxy-DEET est un métabolite majeur de l'insectifuge N-N-diéthyl-méta-toluamide (DEET).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 72236-22-7
Sample solution is provided at 25 µL, 10mM.
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ω-Hydroxy-DEET is a major metabolite of insect repellent N-N-diethyl-meta-toluamide (DEET). ω-Hydroxy-DEET has anti-proliferative effects. DEET is a spatial repellent and an irritant that commonly used to prevent contact with mosquitoes[1][2][3].
Hepatoma cell studies reveals that ω-Hydroxy-DEET (DHMB; 0.1-10 μg/mL; 48-72 hours) treatments decreases cellular proliferation[1].
The metabolite ω-Hydroxy-DEET (DHMB) is extensively distributed following intravenous and topical skin administration of DEET in rats. The ω-Hydroxy-DEET appeared to be the major metabolite for DEET. Repeated once-daily topical application for 30 days lead to higher concentrations of ω-Hydroxy-DEET in the liver[1].
[1]. Daryl J Fediuk, et al. Metabolic disposition of the insect repellent DEET and the sunscreen oxybenzone following intravenous and skin administration in rats. Int J Toxicol. Sep-Oct 2012;31(5):467-76.
[2]. Ryan C Lewis, et al. Urinary biomarkers of exposure to insecticides, herbicides, and one insect repellent among pregnant women in Puerto Rico. Environ Health. 2014 Nov 19;13:97.
[3]. Lu W, et al. DEET as a feeding deterrent. PLoS One. 2017 Dec 14;12(12):e0189243.
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