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P-CAB agent 2

Catalog No.GC71225

P-CAB agent 2 est un puissant bloqueur d'acide compétitif de potassium actif par voie orale et un inhibiteur de la sécrétion d'acide gastrique.

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P-CAB agent 2 Chemical Structure

Cas No.: 1978371-23-1

Taille Prix Stock Qté
1 mg
129,00 $US
En stock
5 mg
291,00 $US
En stock
10 mg
465,00 $US
En stock

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Sample solution is provided at 25 µL, 10mM.

Description Chemical Properties Product Documents
P-CAB agent 2 is a potent and orally active potassium-competitive acid blocker and a gastric acid secretion inhibitor. P-CAB agent 2 inhibits H+/K+-ATPase activity with an IC50 value of <100 nM. P-CAB agent 2 inhibits the hERG potassium channel with an IC50 value of 18.69 M. P-CAB agent 2 shows no acute toxicity and inhibits histamine -induced gastric acid secretion.

P-CAB agent 2 (100 µM) inhibits the hERG potassium channel with an inhibition rate of 86.21% and an IC50 value of 18.69 M[1].

P-CAB agent 2 (example 1) inhibits histamine -induced gastric acid secretion in SD rats[1].
P-CAB agent 2 (600, 2000 mg/kg; p.o.; once) shows no acute toxicity and 600mg/kg shows no significant effect on animal body weight in SD rats[1].

References:
[1]. YinLin Qin, et al. Pyrrole sulfonyl derivative, and preparation method and medical use thereof. WO2016119505A1.

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