PAMP-12 (human, mouse, rat, porcine, bovine) (trifluoroacetate salt) |
Catalog No.GC90548 |
Un fragment peptidique endogène et agoniste de MRGPRX2
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
Proadrenomedullin N-terminal 12 peptide (PAMP-12) is an endogenous peptide fragment found in the adrenal medulla that corresponds to amino acids 9-20 of human PAMP-20 and is involved in potension.1,2,3 It is an agonist of MAS-related G protein-coupled receptor family member X2 (MRGPRX2).2 PAMP-12 inhibits forskolin-induced cAMP accumulation in CHO cells expressing human MRGPRX2 (EC50 = 57.2 nM). It selectively induces calcium mobilization in CHO cells expressing MRGPRX2 (EC50 = 41 nM) over those expressing MRGPRX1, MRGPRX3, or MRGPRX4 at 1 µM. PAMP-12 is an antagonist of nicotinic acetylcholine receptors (nAChRs) that inhibits carbachol-induced catecholamine release (IC50 = 1.3 µM) and calcium and sodium influx (IC50s = 0.39 and 0.87 µM, respectively), but not histamine-induced catecholamine release or calcium and sodium influx (IC50s = >1 µM for all), in primary bovine adrenal chromaffin cells.3 It reduces mean arterial blood pressure in normotensive rats when administered at doses ranging from 10 to 50 nmol/kg.1
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