PD-1/PD-L1 Inhibitor 3 |
| Catalog No.GC16258 |
PD-1/PD-L1 Inhibitor 3, un peptide macrocyclique, est un inhibiteur puissant et sélectif des interactions PD-1/PD-L1 et CD80/PD-L1 extrait du brevet WO2014151634A1, composé n°1. L'inhibiteur 3 de PD-1/PD-L1 interfère avec la liaison de PD-L1 À PD-1 et CD80 en se liant À PD-L1, avec des IC50 de 5,60 nM et 7,04 nM, respectivement. L'inhibiteur 3 de PD-1/PD-L1 peut être utilisé pour la recherche de diverses maladies, y compris le cancer et les maladies infectieuses.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1629654-95-0
Sample solution is provided at 25 µL, 10mM.
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PD-1/PD-L1 Inhibitor 3 is a PD-1/PD-L1 interaction inhibitor.
The anti-PD-1 and anti-PD-L1 compounds have been found to show impressive antitumor effects in various malignancies, such as melanoma. The greatest clinical outcome in unselected patients has been observed in melanoma. The tumor expression of PD-L1 is suggested to be a suggestive, inadequate, and predictive of response to immune-checkpoint blockade.
In vitro: PD-1/PD-L1 inhibitor 3 has been identified to be a potent and selective small molecule inhibitor blocking the interaction of programmed cell death protein 1 (PD-1) with its ligand protein (PD-L1) and with CD80. PD-1/PD-L1 inhibitor 3 was also found to act as an immunomodulator. In addition, PD-1/PD-L1 Inhibitor 3 was found to have highly efficacious binding to PD-L1 and promote the increased functional activities of T cells. Therefore, PD-1/PD-L1 inhibitor 3 could be regarded as a promising therapeutic treatment of cancer and infectious diseases, such as hepatitis C [1].
In vivo: So far, there is no animal in vivo study reported for PD-1/PD-L1 Inhibitor 3.
Clinical trial: Up to now, PD-1/PD-L1 Inhibitor 3 is still in the preclinical development stage.
References:
[1] MILLER Michael Matthew, et al. Patent, Pub. No.:WO/2014/151634
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