Perospirone |
| Catalog No.GC39237 |
La perospirone (base libre SM-9018) est un antagoniste actif par voie orale du récepteur 5-HT2A (Ki = 0,6 nM) et du récepteur de la dopamine D2 (Ki = 1,4 nM), ainsi qu'un agoniste partiel du récepteur 5-HT1A (Ki = 2,9 nM ).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 150915-41-6
Sample solution is provided at 25 µL, 10mM.
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Perospirone (SM-9018 free base) is an orally active antagonist of 5-HT2A receptor (Ki=0.6 nM) and dopamine D2 receptor (Ki=1.4 nM), and also a partial agonist of 5-HT1A receptor (Ki=2.9 nM). Perospirone is an atypical antipsychotic drug and has the potential for schizophrenic disease[1][2].
[1]. Kato T, et al. Binding profile of SM-9018, a novel antipsychotic candidate. pn J Pharmacol. 1990 Dec;54(4):478-81. [2]. Hagiwara H, et al. Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of the antipsychotic drug perospirone: role of serotonin 5-HT1A receptors. Eur Neuropsychopharmacol. 2008 Jun;18(6):448-54.
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