POM 1 (Synonyms: Sodium Metatungstate, Sodium Polyoxotungstate) |
| Catalog No.GC17027 |
Le POM 1 (polyoxotungstate de sodium) est un puissant inhibiteur de l'ectonucléoside triphosphate diphosphohydrolase (ENTPDase), avec des valeurs de Ki de 2,58 μ ; M, 3,26 μ ; M et 28,8 μ ; M pour la NTPDase 1 (CD 39 et CD39), respectivement.
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Cas No.: 12141-67-2
Sample solution is provided at 25 µL, 10mM.
Sodium metatungstate (POM-1) is a potent ecto-nucleoside triphosphate diphosphohydrolase (NTPDase) inhibitor, with Ki values of 2.58 μM, 3.26 μM, and 28.8 μM for NTPDase 1, NTPDase 3 and NTPDase 2 respectively[1]. Sodium metatungstate (POM-1) inhibits ATP breakdown but also blocks central synaptic transmission, an action independent of NTPDase inhibition[2].
References:
[1]. Müller CE, et al. Polyoxometalates--a new class of potent ecto-nucleoside triphosphate diphosphohydrolase (NTPDase) inhibitors. Bioorg Med Chem Lett. 2006 Dec 1;16(23):5943-7.
[2]. Wall et al. The novel NTPDase inhibitor sodium polyoxotungstate (POM-1) inhibits ATP breakdown but also blocks central synaptic transmission, an action independent of NTPDase inhibition. Neuropharmacology. 2008 Dec;55(7):1251-8.
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