Propargyl-PEG3-1-o-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite |
| Catalog No.GC66894 |
Le propargyl-PEG3-1-o-b-cyanoéthyl-NN-diisopropylphosphoramidite est un lieur PROTAC à base de PEG qui peut être utilisé dans la synthèse des PROTAC.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1391728-01-0
Sample solution is provided at 25 µL, 10mM.
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Propargyl-PEG3-1-o-b-cyanoethyl-NN-diisopropylphosphoramidite is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
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