R 568 hydrochloride (Synonyms: KRN 568, NPS R-568, Tecalcet) |
Catalog No.GC17700 |
Le chlorhydrate de R 568 (R 568 Hydrochloride), un composé calcimimétique actif par voie orale, module allostériquement et positivement le récepteur sensible au calcium (CaSR).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 177172-49-5
Sample solution is provided at 25 µL, 10mM.
Tecalcet Hydrochloride (R 568 Hydrochloride), an orally active calcimimetic compound, allosterically and positively modulates the calcium-sensing receptor (CaSR). Tecalcet Hydrochloride (R 568 Hydrochloride) increases the sensitivity to activation by extracellular Ca2+[1][2][3].
References:
[1]. Wada, M., et al. The calcimimetic compound NPS R-568 suppresses parathyroid cell proliferation in rats with renal insufficiency. Control of parathyroid cell growth via a calcium receptor. Journal of Clinical Investigation 100(12), 2977-2983 (1997).
[2]. Nemeth, E.F., et al. The parathyroid calcium receptor: a novel therapeutic target for treating hyperparathyroidism. Pediatr.Nephrol. 10(3), 275-279 (1996).
[3]. Nemeth, E.F., et al. Calcimimetics with potent and selective activity on the parathyroid calcium receptor. Proceedings of the National Academy of Sciences of the United States of America 95(7), 4040-4045 (1998).
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