(R)-BMS-816336 |
Catalog No.GC39029 |
(R)-BMS-816336 (composé 6n-1) est un inhibiteur puissant et actif par voie orale de l'enzyme 11β-hydroxystéroÏde déshydrogénase de type 1 (11β-HSD1) humaine, de souris et de singe cynomolgus avec des IC50 de 14,5 nM, 50,3 nM et 16 nM , respectivement .
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Cas No.: 1009583-83-8
Sample solution is provided at 25 µL, 10mM.
(R)-BMS-816336 (Compound 6n-1) is a potent and orally active inhibitor of human, mouse and cynomolgus monkey 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) enzyme with IC50s of 14.5 nM, 50.3 nM and 16 nM, respectively [1].
[1]. Ye XY, et al. Discovery of Clinical Candidate 2-((2S,6S)-2-Phenyl-6-hydroxyadamantan-2-yl)-1-(3'-hydroxyazetidin-1-yl)ethanone [BMS-816336], an Orally Active Novel Selective 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor. J Med Chem. 2017 Jun 22;60(12):4932-4948.
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