R18 TFA (Synonyms: PHCVPRDLSWLDLEANMCLP TFA) |
Catalog No.GC61601 |
R18 TFA est un peptide antagoniste du 14-3-3, avec un KD de 70-90 nM. R18 bloque efficacement la liaison de 14-3-3 À la kinase Raf-1, un ligand physiologique de 14-3-3, et abolit efficacement le rÔle protecteur de 14-3-3 contre l'inactivation de Raf-1 induite par la phosphatase.
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Sample solution is provided at 25 µL, 10mM.
R18 TFA is a peptide antagonists of 14-3-3, with a KD of 70-90 nM. R18 efficiently blocks the binding of 14-3-3 to the kinase Raf-1, a physiological ligand of 14-3-3, and effectively abolished the protective role of 14-3-3 against phosphatase-induced inactivation of Raf-1[1].
[1]. B Wang, et al. Isolation of high-affinity peptide antagonists of 14-3-3 proteins by phage display. Biochemistry. 1999 Sep 21;38(38):12499-504.
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