RCS-4 N-(5-hydroxypentyl) metabolite-d5

RCS-4 N-(5-hydroxypentyl) metabolite-d₅ contains five deuterium atoms at the 2, 4, 5, 6, and 7 positions. It is intended for use as an internal standard for the quantification of RCS-4 N-(5-hydroxypentyl) metabolite by GC- or LC-mass spectrometry. RCS-4 is structurally similar to certain JWH compounds, synthetic cannabinoids used in herbal mixtures meant to mimic cannabis. RCS-4 itself has been identified in herbal mixtures.¹ RCS-4 N-(5-hydroxypentyl) metabolite is a potential metabolite of RCS-4. A similar JWH metabolite has been detected in human urine following JWH smoking.² This metabolite is almost completely glucuroconjugated in urine samples, requiring enzymolysis of the sample before analysis.²

1.Kikura-Hanajiri, R., Uchiyama, N., and Goda, Y.Survey of current trends in the abuse of psychotropic substances and plants in JapanLeg. Med. (Tokyo)13(3)109-115(2011) 2.Sobolevsky, T., Prasolov, I., and Rodchenkov, G.Detection of JWH-018 metabolites in smoking mixture post-administration urineForensic Sci. Int.200(1-3)141-147(2010)