Relatlimab (Synonyms: BMS-986016) |
| Catalog No.GC66381 |
Relatlimab (BMS-986016) est un anticorps monoclonal humain anti-LAG-3 généré par immunisation de souris transgéniques portant des miniloci d'immunoglobuline humaine avec la protéine LAG-3 recombinante. Le relatlimab bloque l'interaction LAG-3/MHC II avec une valeur IC50 de 0,67 nM et l'interaction LAG-3/FGL1 avec une valeur IC50 de 0,019 nM. Le relatlimab peut être utilisé dans la recherche sur le cancer.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1673516-98-7
Sample solution is provided at 25 µL, 10mM.
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Relatlimab (BMS-986016) is a human monoclonal antibody anti-LAG-3 antibody generated by immunization of transgenic mice bearing human immunoglobulin miniloci with recombinant LAG-3 protein. Relatlimab blocks LAG-3/MHC II interaction with an IC50 value of 0.67 nM and LAG-3/FGL1 interaction with an IC50 value of 0.019 nM. Relatlimab can be used in research of cancer[1].
Relatlimab (BMS-986016; 0.001-100 nM) recognizes native LAG-3 and binds to primary activated human and cynomolgus CD4+ T cells with EC50 values of 0.11 nM and 29.11 nM, respectively[1].
Relatlimab (0.001-10000 nM; T cells (3A9-hLAG-3)) enhances peptide responsiveness of T-cell hybridoma 3A9-hLAG-3 and reversals LAG-3-mediated inhibition of T-cell hybridoma 3A9-hLAG-3 with an IC50 value of 1.05 nM[1].
Relatlimab (0.001-10000 nM; primary T cells) enhances activation of superantigen-stimulated human PBMC cultures and enhances IL-2 secretion[1].
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