1-β-D-Glucosylsphingadienine (d18:2 (4E,8E)) (Synonyms: Glucosylsphingadienine (d18:2 (4E,8E)), 1-β-D-Glucosylsphingadienine (plant), Glucosylsphingosine (plant)) |
| Catalog No.GC42050 |
1-β-D-Glucosylsphingadiénine (d18:2 (4E,8E)) est une glucosylsphingosine, qui sont des dérivés lysolipidiques désacétylés de glucosylcérébrosides.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 114200-59-8
Sample solution is provided at 25 µL, 10mM.
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1-β-D-Glucosylsphingadienine is a glucosylsphingosine, which are deacetylated lysolipid derivatives of glucosylcerebrosides . They are formed when sphingosines undergo glucosidation by UDP-glucose. Glucosylsphingosines completely reduce neurite outgrowth and induce death of LA-N-2 cells at concentrations of 10 and 50 μM, respectively. They also decrease the activity of glucocerebrosidase in LA-N-2 cells in a dose-dependent manner. Glucosylsphingosine levels are elevated in patients with Gaucher's disease, both in the spleen (in types 1, 2, and 3) and brain (type 2 and 3); thus, glucosylsphingosine has been used as a key biomarker of the disease. This product contains 1-β-D-glucosylsphingadienine isolated from plants.
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