20-carboxy Leukotriene B4 (Synonyms: 20carboxy LTB4) |
| Catalog No.GC42082 |
20-carboxy LTB4 is a metabolite of LTB4 in human neutrophils.
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Cas No.: 80434-82-8
Sample solution is provided at 25 µL, 10mM.
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20-carboxy LTB4 is a metabolite of LTB4 in human neutrophils. In human leukocytes, LTB4 is inactivated by the enzyme LTB4 20-hydroxylase. The resulting 20-hydroxy LTB4 is further oxidized to 20-carboxy LTB4. LTB4 metabolism in isolated rat hepatocytes also results in production of 20-carboxy LTB4 along with other ω-oxidation products. The biological activity of 20-carboxy LTB4 is only about 2.6% compared to that of LTB4 in causing PMNL degranulation.
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