3-Mercaptopropionic acid NHS ester |
Catalog No.GC60503 |
L'ester de 3-mercaptopropanyl-N-hydroxysuccinimide est un lieur PROTAC À base d'alkyle/éther qui peut être utilisé dans la synthèse des PROTAC.
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Cas No.: 117235-10-6
Sample solution is provided at 25 µL, 10mM.
3-Mercaptopropanyl-N-hydroxysuccinimide ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.
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