4-Vinylphenol (10%w/w in propylene glycol) |
| Catalog No.GC60525 |
Le 4-vinylphénol se trouve dans l'herbe médicinale Hedyotis diffusa Willd, le riz sauvage et est également le métabolite de l'acide p-coumarique et férulique par les bactéries lactiques du vin. Le 4-vinylphénol induit l'apoptose et inhibe la formation de vaisseaux sanguins et supprime la croissance invasive des tumeurs mammaires in vivo.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2628-17-3
Sample solution is provided at 25 µL, 10mM.
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Product Documents
Quality Control & SDS
4-Vinylphenol is found in the medicinal herb Hedyotis diffusa Willd, wild rice and is also the metabolite of p-coumaric and ferulic acid by lactic acid bacteria in wine. 4-Vinylphenol induces apoptosis and inhibits blood vessels formation and suppresses invasive breast tumor growth in vivo[1].
4-Vinylphenol (12.5-200 µg/mL) significantly reduces cell viability in parental MDA-MB-231 cells, and the IC50 value is 109 µg/mL[1]. 4-Vinylphenol (0.15 or 0.3 µg/mL; 3 days) reduces sphere?formation and vimentin expression on CSCs in breast cancer[1]. 4-Vinylphenol (50, 100 µg/mL; 72 hours) significantly suppresses cell proliferation in CSC-enriched MDA-MB-231 cells. 4-Vinylphenol significantly reduces ALDH1A1 expression by 50% in CSC-enriched MDA-MB-231 cells[1]. 4-Vinylphenol (100 µg/mL) significantly increases the expressions of caspase 3, likely sensitizing CSC-enriched MDAMB-231 cells to apoptosis[1].
[1]. Leung HW, et al. The natural agent 4-vinylphenol targets metastasis and stemness features in breast cancer stem-like cells. Cancer Chemother Pharmacol. 2018 Aug;82(2):185-197.
| Cas No. | 2628-17-3 | SDF | |
| Canonical SMILES | OC1=CC=C(C=C)C=C1 | ||
| Formula | C8H8O | M.Wt | 120.15 |
| Solubility | Storage | -20°C, stored under nitrogen | |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
Complete Stock Solution Preparation Table
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 8.3229 mL | 41.6146 mL | 83.2293 mL |
| 5 mM | 1.6646 mL | 8.3229 mL | 16.6459 mL |
| 10 mM | 0.8323 mL | 4.1615 mL | 8.3229 mL |
In vivo Formulation Calculator (Clear solution)
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
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