5-cis Carbaprostacyclin (Synonyms: (5Z)6aCarbaprostaglandin I2) |
| Catalog No.GC40336 |
5-cis Carbaprostacyclin is a stable analog of PGI2 and an isomer of carbaprostacyclin.
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Cas No.: 69609-77-4
Sample solution is provided at 25 µL, 10mM.
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5-cis Carbaprostacyclin is a stable analog of PGI2 and an isomer of carbaprostacyclin. It is a weak inhibitor of human platelet aggregation with an IC50 of 2.8 µM compared to 0.3 µM for carbaprostacyclin. 5-cis Carbaprostacyclin is a much weaker effector of rabbit mesenteric artery relaxation with an EC50 of 104 µM compared to 5.9 µM for carbaprostacyclin. It even antagonizes the adenylate cyclase activation induced by carbaprostacyclin.
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