7ACC2 |
| Catalog No.GC14642 |
7ACC2 est un puissant inhibiteur du transporteur de monocarboxylate (MCT) avec une IC50 de 11 nM pour l'inhibition de l'influx de [14C]-lactate. 7ACC2 est également un puissant inhibiteur du transport mitochondrial du pyruvate. Le 7ACC2 est un agent anticancéreux par inhibition du flux de lactate.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1472624-85-3
Sample solution is provided at 25 µL, 10mM.
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7ACC2 is a new potent MCT inhibitor with IC50 of 11 nM for inhibition of [14C]-lactate influx; new antitumor treatment targeting lactate transport in cancer cells.IC50 value: 11 nM ([14C]-lactate influx) [1]Target: MCT inhibitor; lactate transport inhibitor7ACC2 did not influence the prothrombin time which, together with a good in vitro ADME profile, supports the potential of this new family of compounds to act as anticancer drugs through inhibition of lactate flux.
References:
[1]. Draoui N, et al. Synthesis and pharmacological evaluation of carboxycoumarins as a new antitumor treatment targeting lactate transport in cancer cells. Bioorg Med Chem. 2013 Nov 15;21(22):7107-17.
Average Rating: 5 (Based on Reviews and 18 reference(s) in Google Scholar.)
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