Ascochlorin (Synonyms: Antibiotic LL-Z1272γ, Ilicicolin D, NSC 287492) |
| Catalog No.GC40715 |
L'ascochlorine (ilicicoline D), un antibiotique isoprénoÏde, médie ses effets anti-tumoraux principalement par la suppression de la cascade de signalisation STAT3.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 26166-39-2
Sample solution is provided at 25 µL, 10mM.
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Ascochlorin is an isoprenoid antibiotic and antiviral that has diverse effects on mammalian cells. It suppresses PMA-induced invasion in renal carcinoma cells (IC50 = ~10 µM) by inhibiting the expression of matrix metalloproteinase-9. At 2 µM, ascochlorin profoundly increases the expression of p53 by increasing protein stability in cancer cells, and, at 50 µm, it inhibits signaling through STAT3. Ascochlorin also binds and inhibits the mitochondrial cytochrome bc1 complex, blocking reduction of cytochrome b by ubiquinone.
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