Belvarafenib (Synonyms: GDC-5573, HM95573) |
| Catalog No.GC32950 |
Belvarafenib (HM95573) est un inhibiteur puissant et pan RAF (Fibrosarcome Rapidement Accéléré), avec des IC50 de 56 nM, 7 nM et 5 nM pour B-RAF, B-RAFv600E et C-RAF respectivement.
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Cas No.: 1446113-23-0
Sample solution is provided at 25 µL, 10mM.
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Belvarafenib is a potent and pan RAF (Rapidly Accelerated Fibrosarcoma) inhibitor, with IC50s of 56 nM, 7 nM and 5 nM for B-RAF, B-RAFv600E and C-RAF respectively.
Belvarafenib (Example 116) is a potent and pan RAF inhibitor with antineoplastic activity. The IC50 values of Belvarafenib are 56 nM, 7 nM and 5 nM for B-RAF, B-RAFv600E and C-RAF respectively. It also shows high inhibitory activity for FMS, DDR1 and DDR2 kinases, with IC50s of 10 nM, 23 nM and 44 nM, respectively[1].
[1]. WO 2013/100632 A1.
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