BSJ-04-132 |
| Catalog No.GC50614 |
BSJ-04-132 est un PROTAC connecté par des ligands pour Cereblon et CDK. BSJ-04-132 est un dégradeur CDK4 puissant et sélectif À base de ribociclib (PROTAC), avec des IC50 de 50,6 nM et 30 nM pour CDK4/D1 et CDK6/D1, respectivement. BSJ-04-132 n'induit pas de dégradation de CDK6 et IKZF1/3. BSJ-04-132 a une activité anticancéreuse.
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Cas No.: 2349356-39-2
Sample solution is provided at 25 µL, 10mM.
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Selective Cdk4 degrader. Degrades Cdk4 in Molt-4 cells, with no effect on Cdk6 levels. Displays cereblon-dependent degradation.
Jiang et al (2019) Development of dual and selective degraders of cyclin-dependent kinases 4 and 6. Angew.Chem.Int.Ed.Engl. 58 6321 PMID:30802347
Average Rating: 5 (Based on Reviews and 24 reference(s) in Google Scholar.)
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