Cearoin |
Catalog No.GC61865 |
Cearoin augmente l'autophagie et l'apoptose par la production de ROS et l'activation de ERK.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 52811-37-7
Sample solution is provided at 25 µL, 10mM.
Cearoin increases autophagy and apoptosis through the production of ROS and the activation of ERK[1].
Cearoin (10-80 µM) induces cell death in a dose-dependent manner[1]. Cearoin (10-80 µM) increases the phosporylation of ERK in SH-SY5Y cells[1]. Cearoin (5-80 µM) increases the conversion of LC3B-I to LC3B-II in SH-SY5Y cells. The expression of LC3B-II is a good marker for autophagosome formation in the autophagy process[1].
References:
[1]. Tonking Bastola, et al. Cearoin Induces Autophagy, ERK Activation and Apoptosis via ROS Generation in SH-SY5Y Neuroblastoma Cells. Molecules. 2017 Feb 6;22(2):242.
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