CH-0793076 TFA (Synonyms: TP3076 TFA) |
Catalog No.GC60692 |
CH-0793076 (TP3076) Le TFA, un analogue de la camptothécine hexacyclique, est le médicament actif et le principal métabolite du TP300. Le CH-0793076 TFA inhibe l'ADN topoisomérase I avec une IC50 de 2,3 μM. Le CH-0793076 TFA est efficace contre les cellules exprimant la BCRP (protéine de résistance au cancer du sein).
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Sample solution is provided at 25 µL, 10mM.
CH-0793076 (TP3076) TFA, a hexacyclic camptothecin analog, is active drug and major metabolite of TP300. CH-0793076 TFA inhibits DNA topoisomerase I with an IC50 of 2.3 μM. CH-0793076 TFA is efficacious against cells expressing BCRP (breast cancer resistance protein)[1].
CH0793076 (TP3076) TFA (6 days at 37°C) shows antiproliferative activity against PC-6/BCRP and PC-6/pRC cells, with IC50s of 0.35 and 0.18 nM, respectively[1].
[1]. Endo M, et al. A water soluble prodrug of a novel camptothecin analog is efficacious against breast cancer resistance protein-expressing tumor xenografts. Cancer Chemother Pharmacol. 2010 Jan;65(2):363-71.
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