Clomiphene citrate (Synonyms: Clomifene, Omifin, NSC 35770) |
| Catalog No.GC15366 |
Le citrate de clomifène (citrate de clomifène) est un modulateur sélectif des récepteurs aux œstrogènes.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 50-41-9
Sample solution is provided at 25 µL, 10mM.
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Clomiphene citrate (Clomifene citrate) is a selective estrogen receptor modulator.Target: Estrogen Receptor/ERRClomifene citrate (CC) acted as an estrogen antagonist regardless of the concentration of E2 added together. In conclusion, CC acts as an estrogen agonist/antagonist via ER alpha in a coexisting estrogen concentration-dependent way whereas it acts as an estrogen antagonist via ER beta whether or not estrogen is present [1]. Clomiphene was effective in increasing pregnancy rate compared to placebo (OR 5.8, 95% CI 1.6 to 21.5) as was clomiphene plus dexamethasone treatment (OR 9.46, 95% CI 5.1 to 17.7) compared to clomiphene alone. A significant improvement in the pregnancy rate was reported for clomiphene plus combined oral contraceptives versus clomiphene alone. No evidence of a difference in effect on pregnancy rate was found with any of the other comparisons [2].
References:
[1]. Kurosawa, T., et al., Clomiphene citrate elicits estrogen agonistic/antagonistic effects differentially via estrogen receptors alpha and beta. Endocr J, 2010. 57(6): p. 517-21.
[2]. Brown, J., et al., Clomiphene and anti-oestrogens for ovulation induction in PCOS. Cochrane Database Syst Rev, 2009(4): p. CD002249.
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