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Desaminotyrosine (3-(4-Hydroxyphenyl)propionic acid)

Catalog No.GC33930

La désaminotyrosine (acide 3-(4-hydroxyphényl)propionique) est un métabolite associé aux microbes protégeant de la grippe grÂce À l'augmentation de la signalisation de l'interféron de type I.

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Desaminotyrosine (3-(4-Hydroxyphenyl)propionic acid) Chemical Structure

Cas No.: 501-97-3

Taille Prix Stock Qté
10mM (in 1mL DMSO)
50,00 $US
En stock
100mg
46,00 $US
En stock

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Sample solution is provided at 25 µL, 10mM.

Description Protocol Chemical Properties Product Documents Related Products

Desaminotyrosine is a microbially associated metabolite protecting from influenza through augmentation of type I interferon signaling.

Wild-type mice produce nanomoles of Desaminotyrosine per gram of feces and have picomolar quantities of Desaminotyrosine in the serum. Desaminotyrosine (200 mM) treatment before influenza infection, protects from influenza by type I interferon (IFN) signaling, with no effect on weight loss or survival in mice with or without vancomycin, neomycin, ampicillin, and metronidazole (VNAM). Desaminotyrosine enhances type I IFN in macrophages via type I IFN amplification in mice[1].

[1]. Steed AL, et al. The microbial metabolite desaminotyrosine protects from influenza through type I interferon. Science. 2017 Aug 4;357(6350):498-502.

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