EB-3D |
| Catalog No.GC39377 |
EB-3D est un inhibiteur puissant et sélectif de la choline kinase α (ChoKα), avec une IC50 de 1 μM pour ChoKα1. EB-3D exerce des effets sur l'expression de ChoKα, l'activation de l'AMPK, l'apoptose, le stress du réticulum endoplasmique et le métabolisme des lipides. EB-3D présente une puissante activité antiproliférative dans un panel de lignées cellulaires de leucémie T. Activité anticancéreuse.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1839150-63-8
Sample solution is provided at 25 µL, 10mM.
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EB-3D is a potent and selective choline kinase α (ChoKα) inhibitor, with an IC50 of 1 μM for ChoKα1. EB-3D induces deregulation of the AMPK-mTOR pathway and apoptosis in leukemia T-cells. EB-3D exhibits a potent antiproliferative activity in a panel of T-leukemia cell lines. Anti-cancer activity[1][2][3].
[1]. Mariotto E, et al. EB-3D a novel choline kinase inhibitor induces deregulation of the AMPK-mTOR pathway and apoptosis in leukemia T-cells. Biochem Pharmacol. 2018 Sep;155:213-223. [2]. Sola-Leyva A, et al. Choline kinase inhibitors EB-3D and EB-3P interferes with lipid homeostasis in HepG2 cells. Sci Rep. 2019 Mar 25;9(1):5109. [3]. Schiaffino-Ortega S, et al. Design, synthesis, crystallization and biological evaluation of new symmetrical biscationic compounds as selective inhibitors of human Choline Kinase α1 (ChoKα1).
Average Rating: 5 (Based on Reviews and 19 reference(s) in Google Scholar.)
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