Fmoc-Ala-Glu-Asn-Lys-NH2 |
| Catalog No.GC61476 |
Fmoc-Ala-Glu-Asn-Lys-NH2 est un peptide inhibiteur sélectif de l'asparagine endopeptidase (AEP) et supprime le clivage de la protéine précurseur amyloÏde (APP).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 220701-06-4
Sample solution is provided at 25 µL, 10mM.
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Fmoc-Ala-Glu-Asn-Lys-NH2 is a selective asparagine endopeptidase (AEP) inhibitor peptide and suppresses amyloid precursor protein (APP) cleavage. AEP, a pH-controlled cysteine proteinase, is activated during ageing and mediates APP proteolytic processing[1].
Fmoc-Ala-Glu-Asn-Lys-NH2 antagonizes APP processing by AEP, whereas other small molecular inhibitors and inactive peptide AEQK were without effect[1].
[1]. Zhang Z, et al. Delta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer's disease. Nat Commun. 2015;6:8762. Published 2015 Nov 9.
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