c-Kit-IN-2 |
| Catalog No.GC35705 |
c-Kit-IN-2 est un inhibiteur de c-KIT avec un IC50 de 82 nM, montre des activités antiprolifératives supérieures contre les trois lignées cellulaires GIST, GIST882, GIST430 et GIST48, avec des GI50 de 3, 1 et 2 nM, respectivement.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2121515-37-3
Sample solution is provided at 25 µL, 10mM.
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c-Kit-IN-2 is a c-KIT inhibitor with an IC50 of 82 nM, shows superior antiproliferative activities against all the three GIST cell lines, GIST882, GIST430, and GIST48, with GI50s of 3, 1, and 2 nM, respectively[1]. IC50: 82 nM (c-KIT)[1]
[1]. Wu TS, et al. Discovery of Conformational Control Inhibitors Switching off the Activated c-KIT and Targeting a Broad Range of Clinically Relevant c-KIT Mutants. J Med Chem. 2019 Apr 25;62(8):3940-3957.
Average Rating: 5 (Based on Reviews and 23 reference(s) in Google Scholar.)
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