E3 ligase Ligand 12 (Synonyms: E3 ligase Ligand 12) |
| Catalog No.GC35926 |
E3 ligase Ligand 12 est le ligand IAP basé sur le dérivé LCL161. Le ligand 12 de la ligase E3 peut être connecté au ligand ABL pour la protéine par un lieur pour former SNIPER.
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Cas No.: 2095244-42-9
Sample solution is provided at 25 µL, 10mM.
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E3 ligase Ligand 12 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 12 can be connected to the ligand for protein by a linker to form PROTACs or SNIPERs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins[1].
[1]. Shibata N, et al. Development of Protein Degradation Inducers of Androgen Receptor by Conjugation of Androgen Receptor Ligands and Inhibitor of Apoptosis Protein Ligands. J Med Chem. 2018 Jan 25;61(2):543-575.
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