Indibulin (Synonyms: D-24851, ZIO 301) |
| Catalog No.GC36308 |
L'indibuline (ZIO 301), un inhibiteur de l'assemblage de la tubuline applicable par voie orale, présente une puissante activité anticancéreuse avec une neurotoxicité minimale.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 204205-90-3
Sample solution is provided at 25 µL, 10mM.
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Indibulin (ZIO 301) , an orally applicable inhibitor of tubulin assembly, shows potent anticancer activity with a minimal neurotoxicity. Indibulin reduces inter-kinetochoric tension, produces aberrant spindles, activates mitotic checkpoint proteins Mad2 and BubR1, and induces mitotic arrest and apoptosis[1]. Tubulin[1]
Indibulin (300-2100 nM; 48 hours) inhibits the proliferation of MCF-7 cells with an IC50 of 150 nM[1]. Indibulin (300, 600 nM; 48 hours) blockes the cells in the G2/M phase indicating that indibulin blockes the progression of the cell cycle at mitosis[1]. Indibulin (150-600 nM; 24 hours) induces apoptosis in MCF-7 cells[1]. Indibulin (150-600 nM; 48 hours) with 300 and 600 nM generates cleaved fragments of PARP protein the treatment of MCF-7 cells[1]. Cell Proliferation Assay[1] Cell Line: MCF-7 cells
[1]. Kapoor S, et al. Indibulin dampens microtubule dynamics and produces synergistic antiproliferative effect with vinblastine in MCF-7 cells: Implications in cancer chemotherapy. Sci Rep. 2018 Aug 17;8(1):12363.
Average Rating: 5 (Based on Reviews and 33 reference(s) in Google Scholar.)
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