TH588 hydrochloride |
| Catalog No.GC37777 |
Le chlorhydrate de TH588 est le premier inhibiteur de la famille des hydrolases nudix qui engage et inhibe de manière puissante et sélective le MTH1 (IC50 = 5 nM).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1640282-30-9
Sample solution is provided at 25 µL, 10mM.
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TH588 hydrochloride is first-in-class nudix hydrolase family inhibitor that potently and selectively engage and inhibit the MTH1 (IC50= 5 nM).
TH588 (2-10μM; 7-10 days) selectively and effectively kills U2OS, HeLa, MDA-MB-231, MCF-7, SW480, and SW620 cells with IC50s of 1.38, 0.83, 1.03, 1.08, 1.72, 0.8 μM [1]. Cell Viability Assay[1] Cell Line: U2OS, HeLa, MDA-MB-231, MCF-7, SW480, SW620, VH10, HDFn cells
TH588 (30 mg/kg; s.c.; once daily for 35 days) reduces tumour growth in SW480 xenograft cancer model[1]. Animal Model: 5-6 weeks female SCID mice (SW480 xenograft cancer model)[1]
[1]. Gad H, et al. MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool. Nature. 2014 Apr 10;508(7495):215-21.
Average Rating: 5 (Based on Reviews and 11 reference(s) in Google Scholar.)
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