VU0453379 |
| Catalog No.GC37929 |
VU0453379 est un modulateur allostérique positif (PAM) pénétrant du système nerveux central (SNC) hautement sélectif du glucagon-like peptide-1R (GLP-1R) avec une CE50 de 1,3 μM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1638646-27-1
Sample solution is provided at 25 µL, 10mM.
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VU0453379 is a highly selective and central nervous system (CNS) penetrant positive allosteric modulator (PAM) of glucagon-like peptide-1R (GLP-1R) with an EC50 of 1.3 μM[1]. EC50: 1.3 μM (GLP-1R)[1]
[1]. Morris LC, et al. Discovery of (S)-2-cyclopentyl-N-((1-isopropylpyrrolidin2-yl)-9-methyl-1-oxo-2,9-dihydro-1H-pyrrido[3,4-b]indole-4-carboxamide (VU0453379): a novel, CNS penetrant glucagon-like peptide 1 receptor (GLP-1R) positive allosteric modulator (PAM). J Med Chem. 2014 Dec 11;57(23):10192-7.
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