IM-54 |
| Catalog No.GC41295 |
IM-54 est un inhibiteur sélectif de la nécrose induite par le stress oxydatif.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 861891-50-1
Sample solution is provided at 25 µL, 10mM.
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IM-54 is an indolylmaleimide derivative which, at 1 μM, inhibits necrotic cell death induced by H2O2 in promyelocytic leukemia HL-60 cells. It does not prevent etoposide-induced apoptosis and does not inhibit protein kinase C or S6 kinase [1]
Reference:
[1]. Dodo, K., Katoh, M., Shimizu, T., et al. Inhibition of hydrogen peroxide-induced necrotic cell death with 3-amino-2-indolylmaleimide derivatives. Bioorganic & Medicinal Chemistry Letters 15(12), 3114-3118 (2005).
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