Microcystin-LA (Synonyms: CyanoginosinLA, Toxin BE4 (M. aeruginosa)) |
| Catalog No.GC18859 |
La microcystine LA, une toxine naturelle, exerce ses effets cytotoxiques en inhibant les sérine-thréonine protéines phosphatases PP1 et PP2A avec des IC50 de 0,3 et 0,3 nM, respectivement.
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Cas No.: 96180-79-9
Sample solution is provided at 25 µL, 10mM.
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Microcystins are hepatotoxic cyclic heptapeptide toxins produced by cyanobacteria. They are responsible for periodic poisonings of humans and livestock following consumption of freshwater in areas where the blue-green algae are endemic. The toxicity of microcystins is initiated by the inhibition of the catalytic activity of protein phosphatase (PP) 1 and PP2A. Microcystin-LA differs from the major microcystin variant LR with the substitution of alanine in place of the arginine. It inhibits both PP1C and PP2A with an IC50 value of 0.3 nM.
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