Nifedipine-d6 |
| Catalog No.GC40207 |
La nifédipine D6 (BAY-a-1040 D6) est de la nifédipine marquée au deutérium, et la nifédipine est un puissant inhibiteur calcique.
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Cas No.: 1188266-14-9
Sample solution is provided at 25 µL, 10mM.
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Nifedipine-d6 is intended for use as an internal standard for the quantification of nifedipine by GC- or LC-MS. Nifedipine is a dihydropyridine L-type calcium channel blocker that reduces the amplitude of spontaneous contractions in isolated rabbit ileum when used at a concentration of 1 μM. Nifedipine (1 μM) reduces TGF-β-induced calcium oscillations in human fibroblasts and prevents impairment of lung function in a mouse model of pulmonary fibrosis induced by bleomycin when administered at a dose of 10 mg/kg per day. It also reduces increases in mean arterial blood pressure induced by angiotensin II in spontaneously hypertensive rats when administered at a dose of 10 μg/kg. Formulations containing nifedipine have been used in the treatment of hypertension and angina.
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